Methyl iodide → dimethyl (2R)-2-methoxybutanedioate

HRID 967615노트

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HRID 967615 반응식
[CH3:1][O:2][C:3](=[O:11])[C@H:4]([OH:10])[CH2:5][C:6]([O:8][CH3:9])=[O:7].[CH3:12]I>C(#N)C.[Ag]=O>[CH3:1][O:2][C:3](=[O:11])[C@H:4]([O:10][CH3:12])[CH2:5][C:6]([O:8][CH3:9])=[O:7]

참가 물질

5

반응물 2

HCID 6328Methyl iodideHCID 110626971,4-dimethyl (2R)-2-hydroxybutanedioate

생성물 1

HCID 2192492dimethyl (2R)-2-methoxybutanedioate수율 88%

시약·촉매·용매 2

HCID 92152Silver(II) oxide촉매HCID 6342Acetonitrile용매

실험 절차

The above (R)-2-hydroxysuccinic acid dimethyl ester was re-dissolved in methyl iodide (100 mL), freshly prepared silver oxide (30.2 g) was added and the mixture was stirred for 24 hours at room temperature. The reaction mixture was diluted with acetonitrile (200 mL), and filtered through celite to remove silver salts and excess silver hydroxide. The filtrate was taken to dryness to leave (R)-2-methoxysuccinic acid dimethyl ester as an oil (23.2 g, 88%).

후처리

  1. filtrationfiltered through celite
  2. customto remove silver salts and excess silver hydroxide

출처 및 근거

ORD 기록
ord-2c04621f6c874692b048da5f311e33b1
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06953812B2

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