Hydroxide → (R)-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino]-2-hydroxypropionic Acid

(R)-3-(4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino]-2-hydroxypropionic acid ethyl ester (0.26 g, 0.38 mmol) was dissolved in ethanol (96%, 15 mL) and added solution hydroxide (4 N, 0.57 mL, 2.3 mmol). After stirring at 25° C. for 1 hour the mixture was evaporated in vacuo, and the residue was added water (30 mL) and acidified with hydrochloric acid (4 N, 0.62 mL). The aqueous phase was extracted twice with ethyl acetate (25 mL and 10 mL) and the combined organic phases were washed with saturated sodium chloride:water (1:1), dried (magnesium sulphate) and concentrated in vacuo to afford 0.21 g of the title compound.

1. customwas evaporated in vacuo
2. additionthe residue was added water (30 mL)
3. extractionThe aqueous phase was extracted twice with ethyl acetate (25 mL and 10 mL)
4. washthe combined organic phases were washed with saturated sodium chloride:water (1:1)
5. dry with materialdried (magnesium sulphate)
6. concentrationconcentrated in vacuo

ORD 기록

ord-804d46cfbd1a47c3a120145be71a127f

출처 데이터셋

uspto-grants-2005_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06953812B2