Sodium Hydroxide → 4-(4-Carbamoylphenoxymethyl)piperidin-4-ol

HRID 967773노트

반응식

HRID 967773 반응식
[OH-:1].[Na+].C([N:10]1[CH2:15][CH2:14][C:13]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)([OH:16])[CH2:12][CH2:11]1)C1C=CC=CC=1>C(O)C>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([O:18][CH2:17][C:13]2([OH:16])[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]2)=[CH:20][CH:21]=1)(=[O:1])[NH2:26]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22291260HCID 22291260, 화합물

생성물 1

HCID 222912804-(4-Carbamoylphenoxymethyl)piperidin-4-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4N sodium hydroxide (6.8 mL) was added to an ethanol solution (30 mL) of the compound (2.2 g) obtained in Step 3 of Example 4 and the mixture was heated under reflux for four and half hours. The solvent was removed under reduced pressure and to the residue was added water (30 mL), and the precipitate was collected by filtration.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for four and half hours
  3. customThe solvent was removed under reduced pressure and to the residue
  4. additionwas added water (30 mL)
  5. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-5276b2473bca4975ad5a3bbbfa9eaf93
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06956046B2

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