Sodium 4-methylbenzenesulfonate → 4-Methylphenylbenzylpiperidinium tosylate

HRID 968172

반응식

HRID 968172 반응식
[Br-].[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]2([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[C:22]1([CH3:32])[CH:27]=[CH:26][C:25]([S:28]([O-:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1.[Na+]>O>[S:28]([C:25]1[CH:26]=[CH:27][C:22]([CH3:32])=[CH:23][CH:24]=1)([O-:31])(=[O:30])=[O:29].[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([N+:9]2([CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 3720192Sodium 4-methylbenzenesulfonateHCID 865888244-Methylphenylbenzylpiperidinium bromide

생성물 1

HCID 865888254-Methylphenylbenzylpiperidinium tosylate수율 91,980.203%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An aqueous solution prepared by dissolving 4-methylphenylbenzylpiperidinium bromide (13.85 g, 0.04 mmol) and sodium p-toluenesulfonate (9.32 g, 0.048 mmol) in 50 ml of deionized water was extracted with 50 ml of chloroform twice by using a separating funnel. The resulting chloroform phases were combined and the combined solution was washed with 50 ml of deionized water, followed by filtration and drying to obtain 4-methylphenylbenzylpiperidinium tosylate (16.1 g, yield: 92%).

후처리

  1. customAn aqueous solution prepared
  2. extractionwas extracted with 50 ml of chloroform twice
  3. washthe combined solution was washed with 50 ml of deionized water
  4. filtrationfollowed by filtration
  5. customdrying

출처 및 근거

ORD 기록
ord-b93f0cc87f6a45a998414276fb93508a
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06958205B2

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