Ammonium Chloride → HCID 178461804, 화합물

HRID 968205노트

반응식

HRID 968205 반응식
[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([S:15]CC3C=CC=CC=3)=[N:6][C:5]=2[N:23]=1.[Na].[Cl-].[NH4+]>N>[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([SH:15])=[N:6][C:5]=2[N:23]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 11857680(2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

생성물 1

HCID 178461804HCID 178461804, 화합물수율 29.7%

시약·촉매·용매 1

HCID 222Ammonia용매

실험 절차

A stirred solution of the product of step (a) (1 g) in liquid ammonia (20 ml) was treated portionwise with sodium until a permanent blue colour was obtained. The solution was treated with ammonium chloride to dissipate the blue colour, and allowed to evaporate. The residue was taken up in water, filtered and purified by reverse phase preparative HPLC on Xterra® C8 column, using 0 to 20% acetonitrile in water at 20 ml/min over 2 min to give the subtitled compound (0.22 g)

후처리

  1. customwas obtained
  2. customto evaporate
  3. filtrationfiltered
  4. custompurified by reverse phase preparative HPLC on Xterra® C8 column
  5. customover 2 min

출처 및 근거

ORD 기록
ord-d5f34948f1bd451db8558f768d8b36c3
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06958343B2

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