Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dibromo-2-nitrobenzene → 4-Bromo-2-nitrobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dibromo-2-nitrobenzene | HCID 77004 | — |
| 반응물 | HCID 178418546 | HCID 178418546 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 4-Bromo-2-nitrobenzonitrile | HCID 292535 | — |
반응 단계
Stir the mixture of 1,4-dibromo-2-nitro-benzene (3.56 mmol) and CuCN (3.74 mmol) in DMA (4 ml) at 100° C. for 5 hours. Cool to room temperature, dilute with EtOAc, filter through celite, wash the organic layer with brine, dry over Na2SO4, and concentrate under vacuum. Purify the residue by flash chromatography (4:1 hexanes/EtOAc) to give 4-bromo-2-nitro-benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07304059B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-599c89686c76459493cd79765109dd75 |
| 출처 메모 | uspto-grants-2007_12 |