Diisopropylethylamine → HCID 178453969, 화합물

HRID 968703노트

반응식

HRID 968703 반응식
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=O)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[C:19]1([CH2:25][CH2:26][CH2:27][CH:28]([NH2:38])[CH2:29][CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(N(CC)C(C)C)(C)C.C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F>C(Cl)Cl>[C:32]1([CH2:31][CH2:30][CH2:29][CH:28]([NH:38][C:15]([C@H:12]2[CH2:11][CH2:10][C@@H:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:14][CH2:13]2)=[O:17])[CH2:27][CH2:26][CH2:25][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 2724699PyBOPHCID 218922551,7-Diphenyl-4-aminoheptane hydrochlorideHCID 178453971HCID 178453971, 화합물

생성물 1

HCID 178453969HCID 178453969, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(tert-Butoxycarbonyl)-cis-4-amino-1-cyclohexanecarboxylic acid (23) (1.00 g; 4.11 mmol) is dissolved in methylene chloride (30 mL) at ambient temperature. 1,7-Diphenyl-4-aminoheptane hydrochloride (1) (1.50 g; 4.93 mmol), N,N-diisopropylethylamine (1.70 g; 13.15 mmol) and PyBOP (2.57 g; 4.93 mmol) are added sequentially. The reaction is stirred 4 hours at room temperature, then concentrated under reduced pressure. The residue is purified via silica gel chromatography (20%<40% ethyl acetate in hexanes) affording the desired product as a solid. CIMS: MH30 493

후처리

  1. concentrationconcentrated under reduced pressure
  2. customThe residue is purified via silica gel chromatography (20%<40% ethyl acetate in hexanes)

출처 및 근거

ORD 기록
ord-50045f722947406f99a705ea8c8f4819
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07304053B2

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