Sodium Hydroxide → 3-{[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]sulfonyl}benzoic acid

HRID 968766노트

반응식

HRID 968766 반응식
[S:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])([OH:3])=[O:2].[O:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[O:19][CH2:20][CH2:21]I.[OH-].[Na+]>O.C(O)C>[O:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[O:19][CH2:20][CH2:21][S:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])=[O:2]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 111186622H-Pyran, tetrahydro-2-(2-iodoethoxy)-HCID 219411183-Sulfinobenzoic acid

생성물 1

HCID 695224113-{[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]sulfonyl}benzoic acid수율 14.8%

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

To a solution of 3-sulfino-benzoic acid (1 g) and 2-iodoethyl tetrahydro-2H-pyran-2-yl ether (1.4 g) in water (20 ml) and ethanol (20 ml) was added NaOH solution to give a pH of 9. The resulting mixture was refluxed for 3 hours before evaporation of the ethanol. The aqueous was acidified to pH3 and the product extracted with EtOAc. The organic layer was separated, dried with MgSO4 and solvent removed by evaporation to give the sub-title compound (0.25 g).

후처리

  1. customto give a pH of 9
  2. extractionthe product extracted with EtOAc
  3. customThe organic layer was separated
  4. dry with materialdried with MgSO4 and solvent
  5. customremoved by evaporation

출처 및 근거

ORD 기록
ord-3c23b48ddc334ca4b63f157b93c14c02
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07304077B2

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