Acetic Anhydride → 3-Acetamido-4-methylbenzoic acid

HRID 968789

반응식

HRID 968789 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(O)(=O)C>[C:12]([NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6])(=[O:14])[CH3:13]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 755683-Amino-4-methylbenzoic acid

생성물 1

HCID 2434323-Acetamido-4-methylbenzoic acid수율 76%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
60 °C

실험 절차

A mixture of 3-amino-4-methylbenzoic acid (13) (27.23 g, 180.2 mmol) and acetic acid (190 mL) is heated to 60° C., and acetic anhydride (120 mL, 1300 mmol) is introduced to the reaction mixture over about 0.25 hours. The reaction mixture is then heated to reflux and stirred for about 30 minutes. The mixture is then cooled to room temperature, and the solid obtained is filtered, washed with water (100 mL), and dried to provide 3-(Acetylamino)-4-methylbenzoic Acid (14) as a light pink colored solid (26.37 g, 76% Yield).

후처리

  1. temperatureThe reaction mixture is then heated
  2. temperatureto reflux
  3. temperatureThe mixture is then cooled to room temperature
  4. customthe solid obtained
  5. filtrationis filtered
  6. washwashed with water (100 mL)
  7. customdried

출처 및 근거

ORD 기록
ord-5656d06a0eba4b70abe4bfc0449c877a
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07304084B2

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