SK&F 81297 → Dopamine

HRID 969924

반응식

CCCN1[C@@H]2CC3C4C(=CC=CC=4NC=3)[C@H]2C[C@@H](CSC)C1.C1[C:33]2[C:28](=[CH:29][C:30]([OH:36])=[C:31]([OH:35])[C:32]=2Cl)[CH:27](C2C=CC=CC=2)[CH2:26][NH:25]C1>>[NH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:35])=[C:30]([OH:36])[CH:29]=1

참가 물질

반응물 2

HCID 1218SK&F 81297

HCID 47811Pergolide

생성물 1

HCID 681Dopamine

실험 절차

HEK cells were transfected with a DNA construct encoding D1-NLS-GFP (1.5 micrograms of DNA), and incubated with the agonist pergolide (10 micromolar) for 48 hours. At 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium containing SKF-81297 (final concentration 10 micromolar). The cells were examined by confocal microscopy.

후처리

additionAt 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium

출처 및 근거

ORD 기록: ord-2520ff19e1914f34831d55f530327735
출처 데이터셋: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07309576B2

연결된 노트

불러오는 중…