반응식
[O:1]=[C:2]1[C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13](OCC)=O)=[O:9])=[CH:6][C:5]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)=[N:4][NH:3]1.O=C1C(C(O)=O)=CC(C2C=CN=CC=2)=NN1.ON1C2C=CC=CC=2N=N1.[Cl:50][C:51]1[CH:52]=C(C=[CH:57][C:58]=1[Cl:59])CN.C(N(CC)C(C)C)(C)C.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1>CN(C)C=O>[Cl:50][C:51]1[CH:52]=[C:12]([CH:13]=[CH:57][C:58]=1[Cl:59])[CH2:11][NH:10][C:8]([C:7]1[C:2](=[O:1])[NH:3][N:4]=[C:5]([C:18]2[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=2)[CH:6]=1)=[O:9]참가 물질
8
반응물 6
HCID 1608Benzenemethanamine, 3,4-dichloro-
HCID 757711-Hydroxybenzotriazole
HCID 81531Diisopropylethylamine
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 10313657Ethyl 3-[(3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carbonyl)amino]propionate
HCID 127902383-Oxo-6-(pyridin-4-yl)-2,3-dihydropyridazine-4-carboxylic acid생성물 1
시약·촉매·용매 1
실험 절차
Working as in example 13 for the preparation of ethyl 3-[(3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carbonyl)amino]propionate, but starting with 0.3 g of 3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxylic acid, 30 cm3 of N,N-dimethylformamide, 0.233 g of 1-hydroxybenzotriazole, 0.19 cm3 of 3,4-dichlorobenzylamine, 0.31 cm3 of N,N-diisopropylethylamine and 0.65 g of O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 0.28 g of N-(3,4-dichlorobenzyl)-3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxamide was obtained in the form of a cream-colored solid melting at 265° C.
출처 및 근거
- ORD 기록
- ord-d5d10d96752a4657ad35f242bbe72fc6
- 출처 데이터셋
- uspto-grants-2007_12
- 특허 번호
- US07309701B2
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