Hydrazine hydrate (1:1) → HCID 25219120, 화합물

HRID 970269노트

반응식

HRID 970269 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11](OC)=[O:12])=[O:6].O.[NH2:22][NH2:23]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([NH:22][NH2:23])=[O:12])=[O:6]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 723590Methyl 3-(3-chlorobenzamido)benzoate

생성물 1

HCID 25219120HCID 25219120, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
65 °C

실험 절차

To a solution of 1.0 gm (3.45 mmol) of methyl 3-(3-chlorobenzamido)benzoate in 24 mL of tetrahydrofuran was added 1.18 mL (34.5 mmol) of hydrazine hydrate. The reaction was heated overnight at 65° C. After cooling, the reaction mixture was concentrated under rotevaporation, and ether and water were added. The solid product was separated by filtration and dried in vacuo to give 3-(3-chlorobenzamido)benzhydrazide. MS m/z: 290.0 (M+H).

후처리

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated under rotevaporation, and ether and water
  3. additionwere added
  4. customThe solid product was separated by filtration
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-6529c36448a44ac8944a27281a11de38
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312181B2

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