Hydrazine hydrate (1:1) → 3-(3-Trifluoromethylbenzamido)benzhydrazide

HRID 970272노트

반응식

HRID 970272 반응식
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12](OC)=[O:13])=[O:7].O.[NH2:25][NH2:26]>O1CCCC1>[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([NH:25][NH2:26])=[O:13])=[O:7]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 850566Methyl 3-(3-trifluoromethylbenzamido)benzoate

생성물 1

HCID 694126823-(3-Trifluoromethylbenzamido)benzhydrazide수율 79%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1.0 gm (3.09 mmol) of methyl 3-(3-trifluoromethylbenzamido)benzoate in 19 mL of tetrahydrofuran was added 1.06 mL (30.9 mmol) of hydrazine hydrate. The reaction was heated to reflux for 48 hr. After cooling, the reaction mixture was concentrated under rotevaporation, and ether and water were added. The solid product was separated by filtration and dried in vacuo to give 785 mg (2.43 mmol, 79% yield) of 3-(3-trifluoromethylbenzamido)benzhydrazide as a white solid. MS m/z: 324.0 (M+H).

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 48 hr
  3. temperatureAfter cooling
  4. concentrationthe reaction mixture was concentrated under rotevaporation, and ether and water
  5. additionwere added
  6. customThe solid product was separated by filtration
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-39dd6924c0bb48c6aa397625a13fbac9
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312181B2

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