Malononitrile → ST050948

HRID 970392

반응식

HRID 970392 반응식
C(N(CC)CC)C.O[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[C:16](#[N:20])[CH2:17][C:18]#[N:19]>CO>[NH2:20][C:16]1[O:15][C:10]2[CH2:11][CH2:12][CH2:13][CH2:14][C:9]=2[C:17]=1[C:18]#[N:19]

참가 물질

5

반응물 3

HCID 8010MalononitrileHCID 8471TriethylamineHCID 10785Cyclohexanone, 2-hydroxy-

생성물 1

HCID 673083ST050948수율 81.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.1 4.8 ml of triethylamine are added dropwise to a solution of 11.0 g of 2-hydroxycyclohexanone and 9.6 g of malononitrile in 25 ml of methanol, and the mixture is stirred at room temperature for a further 4 hours. The crystals which deposit are separated off and washed with methanol, giving 12.8 g of 2-amino-4,5,6,7-tetrahydrobenzofuran-3-carbonitrile (“BA”), m.p. 179°.

후처리

  1. customThe crystals which deposit are separated off
  2. washwashed with methanol

출처 및 근거

ORD 기록
ord-4a7c5bb2c2bb4edc850a4550919d89b8
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312224B2

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