4-Hydroxybiphenyl → 4-Allyloxybiphenyl

HRID 970821노트

반응식

HRID 970821 반응식
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14](Br)[CH:15]=[CH2:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(OCC)C>[CH2:16]([O:13][C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=1)[CH:15]=[CH2:14]

참가 물질

6

반응물 3

HCID 71034-HydroxybiphenylHCID 7841Allyl bromideHCID 11430Potassium Carbonate

생성물 1

HCID 2579864-Allyloxybiphenyl수율 78.9%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

4-Phenylphenol 64 (25.5 g, 0.15 mol), allyl bromide (20.0 g, 0.165 mol) and K2CO3 (41.5 g, 0.15 mol) in 75 ml of dry DMF were stirred at room temperature overnight. The reaction mixture was diluted with 500 ml of diethyl ether and washed with water. The ether layer was washed with brine, dried and concentrated to give a lightly brown solid that was recrystallized from hexane to give 24.9 g of 4-allyloxy-biphenyl 65. Step 2: 3-Allyl-biphenyl-4-ol 66.

후처리

  1. washwashed with water
  2. washThe ether layer was washed with brine
  3. customdried
  4. concentrationconcentrated
  5. customto give a lightly brown solid that
  6. customwas recrystallized from hexane

출처 및 근거

ORD 기록
ord-affd9e0597004eeba78b83a85b550baa
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312230B2

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