Methyl 3-formyl-1H-indole-7-carboxylate → Methyl 3-(hydroxyiminomethyl)indole-7-carboxylate

HRID 971071

반응식

HRID 971071 반응식
[CH:1]([C:3]1[C:11]2[C:6](=[C:7]([C:12]([O:14][CH3:15])=[O:13])[CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1)=O.Cl.[OH:17][NH3+:18]>CN(C)C=O>[OH:17][N:18]=[CH:1][C:3]1[C:11]2[C:6](=[C:7]([C:12]([O:14][CH3:15])=[O:13])[CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 762965Methyl 3-formyl-1H-indole-7-carboxylateHCID 22029257Hydroxyammonium hydrochloride

생성물 1

HCID 136376389Methyl 3-(hydroxyiminomethyl)indole-7-carboxylate수율 97.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5 g of methyl 3-formylindole-7-carboxylate (0.024 mol) are added to a solution of 0.03 mol of hydroxylammonium hydrochloride in dimethylformamide. The reaction mixture is heated at 125° for one hour and subjected to conventional work-up, giving 5.1 g of methyl 3-(hydroxyiminomethyl)indole-7-carboxylate.

후처리

  1. temperatureThe reaction mixture is heated at 125° for one hour

출처 및 근거

ORD 기록
ord-35682b06232f4d1fb4ecb9fe1e25772f
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312342B2

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