Hydrochloric Acid → 2-butylbenzofuran-5-amine Hydrochloride

반응식

[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][C:11]([NH:14]C(=O)C)=[CH:10][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4].[ClH:18]>>[ClH:18].[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 9899437N-(2-Butyl-1-benzofuran-5-yl)acetamide

생성물 1

HCID 98133102-butylbenzofuran-5-amine Hydrochloride수율 88.6%

반응 조건

온도: 2.5 °C

실험 절차

A mixture of N-(2-butyl-5-benzofuranyl)acetamide [10a] (1.16 g, 5.0 mmol) and 15% hydrochloric acid (10 mL) was stirred overnight under reflux conditions and 2 hours at 0-5° C. The precipitated crystals were filtered off, washed on the filter with cold water and ethyl acetate and dried under reduced pressure at 50° C. (water bath) to a constant weight to give 1.00 g (88.6%) of 2-butyl-5-benzofuranamine hydrochloride [12a] as off-white crystalls with mp 189-192° C. (with decomposition).

후처리

filtrationThe precipitated crystals were filtered off
washwashed on the
filtrationfilter with cold water and ethyl acetate
dry with materialdried under reduced pressure at 50° C. (water bath) to a constant weight

출처 및 근거

ORD 기록: ord-31e5a78a2f284e2bbd05a34bddd7aafa
출처 데이터셋: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07312345B2

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