Hydrogen Bromide → HCID 21312053, 화합물

HRID 971847노트

반응식

HRID 971847 반응식
[BrH:1].O[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1>>[ClH:12].[Br:1][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 12296176N-(2-hydroxyethyl)-3-chloroaniline

생성물 1

HCID 21312053HCID 21312053, 화합물수율 146.7%

반응 조건

온도
124 °C

실험 절차

50 gm of 50% hydrobromic acid were slowly added dropwise to 19 gm of the product obtained in step (a), while stirring. The vessel containing the resulting mixture was then connected to a Vigreux-column, and the mixture was heated until a temperature of about 124° C. was reached. After three hours of heating at that temperature, about 35 ml of liquid were distilled off. The residue solidified upon cooling and was purified by washing with acetone, yielding 22 gm of the desired product which had a melting point of 148° C.

후처리

  1. additionThe vessel containing the resulting mixture
  2. distillationwere distilled off
  3. temperatureupon cooling
  4. customwas purified
  5. washby washing with acetone

출처 및 근거

ORD 기록
ord-83b0134809ae452fa16118b493989fcc
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04161528

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