Water → 2-[4-(2-Hydroxyiminocyclohexan-1-ylmethyl)phenyl]propionic Acid

HRID 971868노트

반응식

HRID 971868 반응식
O=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[C:16]([OH:18])=[O:17])=[CH:11][CH:10]=1.Cl.[NH2:21][OH:22].O.O.O.C([O-])(=O)C.[Na+].O>C(O)C>[OH:22][N:21]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[C:16]([OH:18])=[O:17])=[CH:11][CH:10]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 443297Hydroxyamine hydrochlorideHCID 133914932-(4-((2-Oxocyclohexyl)methyl)phenyl)propanoic acidHCID 23665404Sodium Acetate Trihydrate

생성물 1

HCID 737697732-[4-(2-Hydroxyiminocyclohexan-1-ylmethyl)phenyl]propionic Acid수율 107.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 1.3 g of 2-[4-(2-oxocyclohexan-1-ylmethyl)phenyl]propionic acid, 0.33 g of hydroxylamine hydrochloride and 1.6 g of sodium acetate trihydrate in 85% ethanol was heated with stirring at 70°-75° C. for 2 hours, and the mixture was poured into 100 ml of water and extracted with ether. The extract was washed with water, dried over anhydrous sodium sulfate, and the solvent removed by distillation to give 1.4 g of the desired compound, which by recrystallization from a mixture of ethyl acetate and n-hexane afforded colorless prisms, m.p. 143°-150.5° C.

후처리

  1. extractionextracted with ether
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customthe solvent removed by distillation

출처 및 근거

ORD 기록
ord-9ea146a4363d467f8afc88b4fb100801
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04161538

반응 노트

불러오는 중…