Hydrochloric Acid → 3-(1-Pyrrolidinyl)-4-phenoxy-4-sulphamylbenzoic acid

HRID 971891

반응식

HRID 971891 반응식
Cl.[N:2]1([C:7]2[CH:8]=[C:9]([CH:13]=[C:14](N)[C:15]=2[O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]([OH:12])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3]1.N1(C2C=C(C=C([S:45](=[O:48])(=[O:47])[NH2:46])C=2OC2C=CC=CC=2)C(O)=O)CCCC1>>[N:2]1([CH:7]2[C:15]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([S:45](=[O:48])(=[O:47])[NH2:46])[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8]2)[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 4849PiretanideHCID 213120723-(1-Pyrrolidinyl)-4-phenoxy-5-aminobenzoic acid

생성물 1

HCID 706066623-(1-Pyrrolidinyl)-4-phenoxy-4-sulphamylbenzoic acid

실험 절차

The hydrochloride of the 3-(1-pyrrolidinyl)-4-phenoxy-5-aminobenzoic acid is converted in the manner described in Example 35 over the 3-(1-pyrrolidinyl)-4-phenoy-5-chlorosulphonyl-benzoic acid into the desired 3-(1-pyrrolidinyl)-4-phenoxy-5-sulphamylbenzoic acid melting at 225°-226° C.

출처 및 근거

ORD 기록
ord-c86ce8aaf10e4e9da39172bd602fb248
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04161531

연결된 노트

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