Benzene → HCID 13239466, 화합물

HRID 972246노트

반응식

HRID 972246 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][CH:6]([CH2:10][CH3:11])[C:7](O)=[O:8].C1C=CC=CC=1.C(Cl)([Cl:24])=O.Cl>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][CH:6]([CH2:10][CH3:11])[C:7]([Cl:24])=[O:8]

참가 물질

6

반응물 4

HCID 241BenzeneHCID 313Hydrochloric Acid2회HCID 6371Phosgene2회HCID 130607432-(3,5-Dichlorophenoxy)butanoic acid

생성물 1

HCID 13239466HCID 13239466, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
35 °C

실험 절차

71.8 g. (0.288 moles) of α-(3,5-dichlorophenoxy) butyric acid and 75 ml. of benzene are placed in a 500 ml. flask to which a dropping funnel with dry-ice condenser is attached. The slurry is stirred and the 0.2 ml. dimethyl formamide is added. The mixture is heated to 35° C. and 10 g. of phosgene is condensed into the mixture to initiate reaction. The start of the reaction is evidenced by HCl evolution and foaming. 26.0 g. more phosgene is added in 5 gm. increments. At the conclusion of the reaction (HCl evolution ceasing), the reaction mixture is evaporated leaving a residual liquid α-(3,5-dichlorophenoxy) butyryl chloride 77.6g., ND20 = 1.5345

후처리

  1. customflask to which a dropping funnel with dry-ice condenser is attached
  2. customcondensed into the mixture
  3. customreaction
  4. customthe reaction mixture is evaporated

출처 및 근거

ORD 기록
ord-5504110c08274aaf8befd70eb30ff0bf
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04052432

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