Hydrochloric Acid → HCID 21404066, 화합물

HRID 972434노트

반응식

HRID 972434 반응식
C([O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([S:15](Cl)(=[O:17])=[O:16])=[CH:7][CH:6]=1)(=O)C.[CH2:19]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30].C(N(CC)CC)C.[OH-].[K+].Cl>CCOCC.O.C(#N)C>[CH2:32]([N:31]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[S:15]([C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([OH:4])=[CH:6][CH:7]=1)(=[O:16])=[O:17])[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43]

참가 물질

9

반응물 5

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 14797Potassium HydroxideHCID 18157DidodecylamineHCID 214040784-(Chlorosulfonyl)naphthalen-1-yl acetate

생성물 1

HCID 21404066HCID 21404066, 화합물

시약·촉매·용매 3

HCID 962Water용매2회HCID 3283Diethyl Ether용매HCID 6342Acetonitrile용매

실험 절차

A mixture of 18.1 g (0.063 mole) 1-acetoxy-4-naphthalenesulfonyl chloride, 22.4 g (0.063 mole) N,N-didodecylamine, 25 ml (18.1 g, 0.18 mole) triethylamine, and 200 ml acetonitrile was stirred at room temperature for 18 hrs. The mixture was diluted with ether and poured into water. The ether layer was separated, dried, and concentrated to 16.1 g of an amber oil, which was dissolved in 100 ml ethanol. To the solution was added 1.50 g (0.027 mole) potassium hydroxide; the mixture was stirred at room temperature for 2 days, acidified with hydrochloric acid, and diluted with water. The mixture was extracted with ether, and the extract was concentrated to 30.7 g of an amber oil, which partially crystallized.

후처리

  1. customThe ether layer was separated
  2. customdried
  3. concentrationconcentrated to 16.1 g of an amber oil, which
  4. dissolutionwas dissolved in 100 ml ethanol
  5. stirringthe mixture was stirred at room temperature for 2 days
  6. extractionThe mixture was extracted with ether
  7. concentrationthe extract was concentrated to 30.7 g of an amber oil, which
  8. custompartially crystallized

출처 및 근거

ORD 기록
ord-e250f05f53624c4dbb883b29fb802961
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04053312

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