Ethanol → 4-Hydrazinyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

반응식

Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]2[NH:8][N:9]=[CH:10][C:3]=12.O.[NH2:12][NH2:13].[CH2:14](O)C>>[NH:12]([C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH3:14])[N:9]=[CH:10][C:3]=12)[NH2:13]

참가 물질

반응물 3

HCID 702Ethanol2회

HCID 24654Hydrazine hydrate (1:1)

HCID 2210954-Chloro-1H-pyrazolo[3,4-d]pyrimidine

생성물 1

HCID 2197854-Hydrazinyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

실험 절차

50 g. of 4-chloropyrazolo[3,4-d]pyrimidine are dissolved in 700 ml. of absoulute ethanol and 25 g. of hydrazine hydrate in 100 ml. of ethanol are slowly added dropwise with stirring. This is stirred for 13 hours at room temperature and the product formed is then filtered under suction, water is added and the product, 4-hydrazino-1-methylpyrazolo[3,4-d]pyrimidine, is crystallized from dimethylformamide as yellowish crystals, m.p. 231°.

후처리

stirringThis is stirred for 13 hours at room temperature
customthe product formed
filtrationis then filtered under suction, water
additionis added
customthe product, 4-hydrazino-1-methylpyrazolo[3,4-d]pyrimidine, is crystallized from dimethylformamide as yellowish crystals, m.p. 231°

출처 및 근거

ORD 기록: ord-2da7edcef5024c9eaa39f1a89d35c165
출처 데이터셋: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04053474

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