Sodium Hydroxide → N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea

반응식

C([NH:9][C:10]([NH:12][CH:13]1[C:21]2[CH:20]=[CH:19][S:18][C:17]=2[CH2:16][CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>>[S:18]1[CH:19]=[CH:20][C:21]2[CH:13]([NH:12][C:10]([NH2:9])=[O:11])[CH2:14][CH2:15][CH2:16][C:17]1=2

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 130370061-Benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl)urea

생성물 1

HCID 13036998N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea

실험 절차

A mixture of 1-benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl) urea and 2N aqueous sodium hydroxide solution (5ml) is stirred at reflux for 2.5 hours. The mixture is cooled in ice, the product is collected and washed with water to afford 0.58 g of title compound, m.p. 203° to 207° C.

후처리

temperatureat reflux for 2.5 hours
temperatureThe mixture is cooled in ice
customthe product is collected
washwashed with water

출처 및 근거

ORD 기록: ord-14391dd763914b96a03eb547db6e1b88
출처 데이터셋: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04053484

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