4-Nitrophthalic acid anhydride → 1-n-Butyl-4-(4-nitrophthalimido)piperidine

HRID 972816노트

반응식

HRID 972816 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:4][CH2:3]1.[N+:12]([C:15]1[CH:16]=[C:17]2[C:22](=O)[O:21][C:19](=[O:20])[C:18]2=[CH:24][CH:25]=1)([O-:14])=[O:13]>C(Cl)(Cl)Cl>[CH2:8]([N:5]1[CH2:6][CH2:7][CH:2]([N:1]2[C:22](=[O:21])[C:17]3=[CH:16][C:15]([N+:12]([O-:14])=[O:13])=[CH:25][CH:24]=[C:18]3[C:19]2=[O:20])[CH2:3][CH2:4]1)[CH2:9][CH2:10][CH3:11]

참가 물질

4

반응물 2

HCID 2309764-Nitrophthalic acid anhydrideHCID 122628201-Butylpiperidin-4-amine

생성물 1

HCID 537449311-n-Butyl-4-(4-nitrophthalimido)piperidine

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

4.69 Grams of 4-amino-1-n-butylpiperidine in 100 milliliters of chloroform were added to a suspension of 5.79 grams of 4-nitrophthalic anhydride in 75 milliliters of chloroform and the solution was evaporated to dryness. 40 Milliliters of acetic anhydride were added and the mixture was then heated on a steam bath for half an hour. The excess acetic anhydride was evaporated off and the residue dissolved in 40 milliliters of methanol and ethereal hydrogen chloride was added to give a solid which was collected giving 2.50 grams of the title compound as the monohydrochloride.

후처리

  1. customthe solution was evaporated to dryness
  2. addition40 Milliliters of acetic anhydride were added
  3. temperaturethe mixture was then heated on a steam bath for half an hour
  4. customThe excess acetic anhydride was evaporated off
  5. dissolutionthe residue dissolved in 40 milliliters of methanol
  6. additionethereal hydrogen chloride was added
  7. customto give a solid which
  8. customwas collected

출처 및 근거

ORD 기록
ord-d062ba32e1f64c5a8471b9811b6f7a75
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04053615

반응 노트

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