p-Piperidinophenol → HCID 21405650, 화합물

HRID 972890노트

반응식

HRID 972890 반응식
[Na].[N:2]1([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.Br[CH:16]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:17]([O:19]CC)=[O:18]>C(O)C>[C:22]1([CH:16]([O:14][C:11]2[CH:10]=[CH:9][C:8]([N:2]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]3)=[CH:13][CH:12]=2)[C:17]([OH:19])=[O:18])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 90452p-PiperidinophenolHCID 97780Ethyl bromophenylacetateHCID 5360545Sodium

생성물 1

HCID 21405650HCID 21405650, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.3 g. of sodium is dissolved in 100 ml. of absolute ethanol; 17.7 g. of 4-piperidinophenol is introduced into the solution, and then 24.3 g. of ethyl α-bromophenylacetate is added dropwise thereto and the mixture refluxed for 10 hours. The reaction mixture is then evaporated, the residue mixed with water, and the aqueous solution extracted with ethyl acetate. The ethyl acetate solution is washed twice with dilute KOH and twice with water, then dried, and the solvent is evaporated, thus obtaining the ethyl ester of α-phenyl-α-4-piperidinophenoxy-acetic acid; hydrochloride, m.p. 149°-151°.

후처리

  1. temperaturethe mixture refluxed for 10 hours
  2. customThe reaction mixture is then evaporated
  3. additionthe residue mixed with water
  4. extractionthe aqueous solution extracted with ethyl acetate
  5. washThe ethyl acetate solution is washed twice with dilute KOH and twice with water
  6. customdried
  7. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-99c6fc8562064e6bad38c78bb67fceca
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04053626

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