1-Hexanol → Hexyl 2-hydroxy-2-methylpropanoate

HRID 973185

반응식

[OH:1][C:2]([CH3:7])([CH3:6])[C:3](N)=[O:4].[CH2:8]([OH:14])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>>[CH2:8]([O:14][C:3](=[O:4])[C:2]([OH:1])([CH3:7])[CH3:6])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

참가 물질

반응물 2

HCID 81031-Hexanol

HCID 83059Propanamide, 2-hydroxy-2-methyl-

생성물 1

HCID 21401559Hexyl 2-hydroxy-2-methylpropanoate수율 51.8%

실험 절차

A mixture of 20.6 g of α-hydroxy-isobutyramide and 204 g of n-hexyl alcohol was heated in the presence of 0.45 g of PbO for 6 hours at 200° C. in an autoclave. On working up by distillation, 19.5 g (= 51.8 percent of theory) of α-hydroxy-isobutyric acid-n-hexyl-ester were obtained. The amide conversion is 75 percent.

후처리

distillationOn working up by distillation

출처 및 근거

ORD 기록: ord-cd14d858d59547409c78185637444a00
출처 데이터셋: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04055590

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