Ethanol → HCID 21401589, 화합물

HRID 973197노트

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HRID 973197 반응식
[O:1]1[CH2:22][CH:2]1[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8].[OH-:23].[Na+].[CH2:25](O)[CH3:26]>O>[OH:23][CH:2]([CH2:22][O:1][CH2:25][CH3:26])[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:7]([CH3:10])(=[O:8])=[O:9]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 21401575ethyl 7-[N-(4,5-epoxypentyl)methanesulfonamido]heptanoate

생성물 1

HCID 21401589HCID 21401589, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of ethyl 7-[N-(4,5-epoxypentyl)- methanesulfonamido]heptanoate (7.0g., 0.02 mole) in ethanol (150 ml.) is added sodium hydroxide (1.84 g., 0.046 mole) dissolved in water (15 ml.). This solution is stirred at room temperature for 18 hours, then concentrated to one-half volume under reduced pressure. Water (150 ml.) is added and this aqueous solution is extracted with ether (2 × 100 ml.). The aqueous layer is then acidified (dilute hydrochloric acid) and extracted with ethyl acetate (2 × 150 ml.). The organic phase is washed with brine, dried over sodium sulfate, then evaporated in vacuo. The yield of subject compound is 4.0 g. (54%) of pale yellow oil.

후처리

  1. concentrationconcentrated to one-half volume under reduced pressure
  2. additionWater (150 ml.) is added
  3. extractionthis aqueous solution is extracted with ether (2 × 100 ml.)
  4. extractionextracted with ethyl acetate (2 × 150 ml.)
  5. washThe organic phase is washed with brine
  6. dry with materialdried over sodium sulfate
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-4426bf2078cb4265afad9b7000ddc2eb
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04055596

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