Phosphorus oxychloride → 4-Chloroquinazolin-2-amine

반응식

[NH2:1][C:2]1[NH:11][C:10](=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.P(Cl)(Cl)([Cl:15])=O>>[NH2:1][C:2]1[N:11]=[C:10]([Cl:15])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 1354038142-Amino-3H-quinazolin-4-one

생성물 1

HCID 104422884-Chloroquinazolin-2-amine수율 19%

실험 절차

2-Amino-4-(3H)-quinazolone (2.0 g, 0.0124 mol) was heated under reflux in phosphoryl chloride (19.02 g, 0.0124 mol) for 2.5 hours. The reaction mixture was partitioned between chloroform, ice and NaOH solution (pH 9) and the organic phase dried, filtered, excess solvent removed and the residue triturated with chloroform to give 2-amino-4-chloroquinazoline (0.42 g, 19%) m.p. 275°-278°.

후처리

customThe reaction mixture was partitioned between chloroform, ice and NaOH solution (pH 9)
customthe organic phase dried
filtrationfiltered
customexcess solvent removed
customthe residue triturated with chloroform

출처 및 근거

ORD 기록: ord-a00b58d881d04dd3ad21ea4e7e30bf0e
출처 데이터셋: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05064833

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