Ethyl 3-aminopropyl(phenyl)phosphinate → 3-Aminopropyl(phenyl)phosphinic acid

HRID 973605노트

반응식

HRID 973605 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:9])[O:6]CC>Cl>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:6])[OH:9]

참가 물질

3

반응물 1

HCID 19090874Ethyl 3-aminopropyl(phenyl)phosphinate

생성물 1

HCID 101042063-Aminopropyl(phenyl)phosphinic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 6.83 g of ethyl 3-aminopropyl(phenyl)phosphinate and 30 ml of 20% hydrochloric acid is refluxed with stirring for 4 hours. The clear solution is evaporated to dryness and the residue is recrystallized from methanol/propylenoxide to give 3-aminopropyl(phenyl)phosphinic acid as a white solid, m.p. 298°-300°.

후처리

  1. temperatureis refluxed
  2. customThe clear solution is evaporated to dryness
  3. customthe residue is recrystallized from methanol/propylenoxide

출처 및 근거

ORD 기록
ord-1661deeda1b743d8a6217bb1de4c57d2
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064819

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