Methane → 2-(2,6-Dichloro-4-trifluoromethylphenylhydrazono)propanal 1-oxime

HRID 973675

반응식

HRID 973675 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][NH2:14].O=[C:16]([CH3:20])[CH:17]=[N:18][OH:19].S([O-])([O-])(=O)=O.[Mg+2].C>CCOCC>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:11])[F:10])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][N:14]=[C:16]([CH3:20])[CH:17]=[N:18][OH:19]

참가 물질

6

반응물 4

HCID 297MethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 688223[2,6-Dichloro-4-(trifluoromethyl)phenyl]hydrazineHCID 63992132-Oxopropanal-1-oxime

생성물 1

HCID 1363412052-(2,6-Dichloro-4-trifluoromethylphenylhydrazono)propanal 1-oxime

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of 2,6-dichloro-4-trifluoromethylphenylhydrazine (10.2 g) in ether (15 ml) was added with cooling to a solution of `2-oxopropanal 1-oxime (3.62 g) in ether (15 ml) at 0°. The mixture was stirred at room temperature overnight and magnesium sulphate and charcoal added. The mixture was filtered and solvent evaporated under reduced pressure. The residue was purified by column chromatography to give 2-(2,6-dichloro-4-trifluoromethylphenylhydrazono)propanal 1-oxime, m.p, c.108°.

후처리

  1. filtrationThe mixture was filtered
  2. customsolvent evaporated under reduced pressure
  3. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-f5e3e5b3d37946958d7541f859f44bf7
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064844

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