tert-butyl N-(4-aminobutyl)carbamate → N-(tert-butoxycarbonyl)-N'-(1-naphthyl acetyl)-1,4-diamino-butane

HRID 973729

반응식

HRID 973729 반응식
[C:1]1([CH2:11][C:12](Cl)=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])=[O:21])([CH3:18])([CH3:17])[CH3:16].C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:12](=[O:13])[CH2:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

참가 물질

5

반응물 3

HCID 4351tert-butyl N-(4-aminobutyl)carbamateHCID 8471TriethylamineHCID 27953862-(Naphthalen-1-yl)acetyl chloride

생성물 1

HCID 19989015N-(tert-butoxycarbonyl)-N'-(1-naphthyl acetyl)-1,4-diamino-butane수율 97.9%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of 16.3 g of 1-naphthyl-acetic acid chloride in 80 ml of chloroform was added at +10° C. to a solution cooled to +10° C. of 15 g of N-(tert-butoxycarbonyl)-1,4-diamino butane, 100 ml of chloroform and 14 ml of triethylamine and after one hour of stirring at ambient temperature, the mixture was concentrated to dryness under reduced pressure. The residue was taken up in water, separated and dried under reduced pressure at 50° C. to obtain 27.8 g of the expected product.

후처리

  1. concentrationthe mixture was concentrated to dryness under reduced pressure
  2. customseparated
  3. customdried under reduced pressure at 50° C.

출처 및 근거

ORD 기록
ord-62f119eefb404bb29accddb1e10d90ea
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064861

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