Sodium Chloride → HCID 15667144, 화합물

HRID 973770

반응식

HRID 973770 반응식
[Na].[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7](Cl)=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1.[O-:28][CH2:29][CH2:30][CH3:31].[Na+].[Cl-]>C(O)CC>[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7]([O:28][CH2:29][CH2:30][CH3:31])=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 5360545SodiumHCID 125435151-Propanol, ion(1-)HCID 15667140HCID 15667140, 화합물

생성물 1

HCID 15667144HCID 15667144, 화합물

시약·촉매·용매 1

HCID 10311-Propanol용매2회

실험 절차

51 mg sodium was dissolved in 5 ml n-propanol. 670 mg of the above product (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-chloro-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine dissolved in 15 ml n-propanol was added to the propoxide solution with stirring. After 1 hour the reaction was poured into 200 ml saturated NaCl and the extracts were dried over MgSO4, filtered and concentrated to yield an oil which was purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate) to yield 600 mg of (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-propoxy-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine.

후처리

  1. dry with materialthe extracts were dried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customto yield an oil which
  5. customwas purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate)

출처 및 근거

ORD 기록
ord-977b111411004781a6cca546565ac9e0
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064947

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