Isopropyl iodide → Methyl 2-cyano-3-methylbutanoate

HRID 973781노트

반응식

HRID 973781 반응식
[Na].[C:2]([CH2:4][C:5]([O:7][CH2:8]C)=[O:6])#[N:3].[CH:10](I)([CH3:12])[CH3:11]>CO>[CH:10]([CH:4]([C:2]#[N:3])[C:5]([O:7][CH3:8])=[O:6])([CH3:12])[CH3:11]

참가 물질

5

반응물 3

HCID 6362Isopropyl iodideHCID 7764Ethyl cyanoacetateHCID 5360545Sodium

생성물 1

HCID 557651Methyl 2-cyano-3-methylbutanoate수율 79.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In 20 ml of absolute methanol was dissolved 520 mg of metallic sodium, and 2.12 g of ethyl cyanoacetate was added thereto with stirring at room temperature, after which 4.0 g of isopropyl iodide was added dropwise over a period of 10 minutes. After completion of the dropwise addition, the resulting mixture was stirred at room temperature for 3 hours, refluxed for 1 hour, subjected to a conventional post-treatment, and then distilled under reduced pressure to obtain 2.1 g of methyl α-isopropylcyanoacetate.

후처리

  1. additionwas added
  2. additionAfter completion of the dropwise addition
  3. stirringthe resulting mixture was stirred at room temperature for 3 hours
  4. temperaturerefluxed for 1 hour
  5. distillationdistilled under reduced pressure

출처 및 근거

ORD 기록
ord-598568fcc2bd405e9db646a1f4eff1dd
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064945

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