Hydrochloric Acid → Methyl 1H-pyrazole-4-carboxylate

HRID 973903노트

반응식

HRID 973903 반응식
Cl.[NH:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[N:3]1.[CH3:10]O>>[C:7]([C:5]1[CH:6]=[N:2][NH:3][CH:4]=1)([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3015937Pyrazole-4-carboxylic acid

생성물 1

HCID 9793760Methyl 1H-pyrazole-4-carboxylate수율 79.6%

반응 조건

온도
0 °C

실험 절차

To an ice cold saturated solution of HCl in methanol (500 ml), pyrazole-4-carboxylic acid (4) (19.2 g, 0.17 m) was added and the solution stirred at 0° C. for 3 hours and at ambient temperature overnight. The solvent was distilled off and the brown residue was dissolved in water. The aqueous solution was neutralized with NaHCO3 and the product was repeatedly extracted with ether (25×100 ml). The ether extract was dried over Mg SO4 and concentrated to give the methyl ester (5) as a pale yellow solid (13.59 g, 79.6%).

후처리

  1. distillationThe solvent was distilled off
  2. dissolutionthe brown residue was dissolved in water
  3. extractionthe product was repeatedly extracted with ether (25×100 ml)
  4. extractionThe ether extract
  5. dry with materialwas dried over Mg SO4
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9d6c41211e5a4b94b67faddd3872272f
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05066479

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