Water → 1,4-Bisacetylamino-2-fluorobenzene

HRID 974143노트

반응식

HRID 974143 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[C:4]([F:12])[CH:3]=1.O.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)(=O)C>[C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:14](=[O:16])[CH3:15])=[CH:3][C:4]=1[F:12])(=[O:11])[CH3:10]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 255648n-(4-Amino-2-fluorophenyl)acetamide

생성물 1

HCID 148170801,4-Bisacetylamino-2-fluorobenzene

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
15 °C

실험 절차

134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried.

후처리

  1. customThe product which has precipitated
  2. filtrationis then filtered off
  3. washwashed twice with 150 ml of water each time
  4. customdried

출처 및 근거

ORD 기록
ord-4acb91097a55474a9d82e95b0a27f20a
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05067967

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