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4-tert-Butylcyclohexanone → HCID 14406817, 화합물

HRID 974180
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HRID 974180 반응식
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[C:12]([C:16]1[CH:21]=[CH:20][C:19]([CH:22]2[CH2:26][CH2:25][NH:24][CH2:23]2)=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13].C([BH3-])#N.[Na+]>CO.[Cl-].[Zn+2].[Cl-]>[C:1]([CH:5]1[CH2:10][CH2:9][CH:8]([N:24]2[CH2:25][CH2:26][CH:22]([C:19]3[CH:20]=[CH:21][C:16]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:17][CH:18]=3)[CH2:23]2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 73924-tert-ButylcyclohexanoneHCID 5003444Sodium cyanoborohydrideHCID 144068163-(4-(1,1-Dimethylethyl)phenyl)pyrrolidine

생성물 1

HCID 14406817HCID 14406817, 화합물

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 887Methanol용매

실험 절차

15.4 g (100 millimoles) of 4-tert-butylcyclohexanone, 9.8 g (48 millimoles) of 3-(4-tert-butylphenyl)-pyrrolidine, 6.8 g (50 millimoles) of zinc(II) chloride and 6.3 g (100 millimoles) of sodium cyanoborohydride in 200 ml of absolute methanol were stirred for 48 hours at 22° C. The methanol was distilled off under reduced pressure and the residue was dissolved in dichloromethane and 5% strength sodium hydroxide solution.

후처리

  1. distillationThe methanol was distilled off under reduced pressure
  2. dissolutionthe residue was dissolved in dichloromethane

출처 및 근거

ORD 기록
ord-b6c1614e8ca847e8ba6d23843b2b98c1
출처 데이터셋
uspto-grants-1991_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05068245

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