Potassium Carbonate → 2-Amino-6-(3-(3-chloro-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974292

반응식

HRID 974292 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[CH:5]=[CH:6][CH2:7]Cl.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1.C(=O)([O-])[O-].[K+].[K+]>C(Cl)(Cl)Cl>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:7][CH:6]=[CH:5][C:4]3[CH:9]=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=3)[CH2:19][CH2:20][C:21]=2[N:22]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 538328553-Chloro-cinnamyl chloride

생성물 1

HCID 536944422-Amino-6-(3-(3-chloro-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine수율 20%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Prepared from 3-chloro-cinnamyl chloride and 1 equivalent of 2-amino-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine in chloroform in the presence of 1 equivalent of potassium carbonate. Yield: 20% of theory, Melting point: 132°-136° C.

출처 및 근거

ORD 기록
ord-9f5e06e4392f4ef5a0ace45abf14d621
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068325

연결된 노트

불러오는 중…