홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → (3-(4-Methoxy-phenyl)propionyl-amino)-6-(3-(3-pyridyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974333
노트
인쇄 미리보기

반응식

HRID 974333 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12][CH:13]=[CH:14][C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1.C(N(CC)CC)C.[CH3:28][O:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][C:38](Cl)=[O:39])=[CH:32][CH:31]=1>C(Cl)(Cl)Cl>[CH3:28][O:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][C:38]([NH:1][C:2]2[S:3][C:4]3[CH2:5][CH2:6][N:7]([CH2:12][CH:13]=[CH:14][C:15]4[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=4)[CH2:8][CH2:9][C:10]=3[N:11]=2)=[O:39])=[CH:32][CH:31]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 109324413-(4-Methoxyphenyl)propionyl chlorideHCID 543192542-Amino-6-(3-(3-pyridyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepin

생성물 1

HCID 53917232(3-(4-Methoxy-phenyl)propionyl-amino)-6-(3-(3-pyridyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a stirred mixture of 1.0 g (3.5 mmol) of 2-amino-6-(3-(3-pyridyl)allyl)-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine and 0.53 ml (3.8 mmol) of triethylamine in 40 ml of anhydrous chloroform, there is added dropwise at ambient temperature a solution of 3- (4-methoxy-phenyl)-propionyl chloride (bp: 150° C./15 torr) in 7 ml of chloroform. The mixture is stirred for 3 hours at 60°-70° C., cooled and extracted with water. The dried and filtered chloroform solution is evaporated down in vacuo and the evaporation residue is purified by column chromatography on silica gel (chloroform/methanol=5:1). Yield: 0.74 g (47% of theory), Melting point: 168°-170° C. (ether).

후처리

  1. temperaturecooled
  2. extractionextracted with water
  3. customThe dried
  4. filtrationfiltered chloroform solution
  5. customis evaporated down in vacuo
  6. customthe evaporation residue is purified by column chromatography on silica gel (chloroform/methanol=5:1)

출처 및 근거

ORD 기록
ord-f1966946c99d4787a99f59d462f80082
출처 데이터셋
uspto-grants-1991_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05068325

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트