2,4-Dimethoxytetrahydrofuran → 1-[3-(2,4-Difluorophenyl)propyl]-1H-pyrrole

반응식

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][NH2:12].CO[CH:15]1[CH2:19][CH:18](OC)[CH2:17]O1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][N:12]1[CH:15]=[CH:19][CH:18]=[CH:17]1

참가 물질

반응물 2

HCID 199863682,4-Dimethoxytetrahydrofuran

HCID 226691392,4-Difluoro-benzenepropanamine

생성물 1

HCID 199863711-[3-(2,4-Difluorophenyl)propyl]-1H-pyrrole

실험 절차

17.1 g (0.10 mol) of 3-(2,4-difluorophenyl)propylamine are heated at 260° C. for 2 hours in an autoclave with 13.2 g (0.10 mol) of 2,4-dimethoxytetrahydrofuran. The reaction mixture is cooled and then purified by vacuum distillation. 10.6 g (48% of theory) of a colourless oil which boils at 80° C. and 0.2 mbar or 146°-147° C. and 15 mbar are obtained.

후처리

temperatureThe reaction mixture is cooled
distillationpurified by vacuum distillation
custom10.6 g (48% of theory) of a colourless oil which boils at 80° C. and 0.2 mbar or 146°-147° C. and 15 mbar are obtained

출처 및 근거

ORD 기록: ord-54f1e1a3b3494f0d8649e77445d4fe39
출처 데이터셋: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05068371

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