3-Chloropropionitrile → HCID 178511037, 화합물

HRID 974428노트

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HRID 974428 반응식
[S:1]([NH2:5])([NH2:4])(=[O:3])=[O:2].Cl[C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Cl:14])[C:8]=1[S:15]([OH:18])(=[O:17])=[O:16].[Cl:19][CH2:20][CH2:21][C:22]#[N:23]>C(Cl)Cl.CC(C)=O>[Cl:14][C:9]1[CH:10]=[C:11]([Cl:13])[C:12]([Cl:19])=[CH:7][C:8]=1[S:15]([OH:18])(=[O:17])=[O:16].[S:1]([NH:5][C:22](=[NH:23])[CH2:21][CH2:20][Cl:19])(=[O:3])(=[O:2])[NH2:4]

참가 물질

6

반응물 3

HCID 109633-ChloropropionitrileHCID 82267SulfamideHCID 1286712,4,6-Trichlorobenzenesulfonate

생성물 1

HCID 178511037HCID 178511037, 화합물

시약·촉매·용매 2

HCID 180Acetone용매HCID 6344Dichloromethane용매

반응 조건

온도
57.5 °C

실험 절차

Sulfamide (9.6 g, 0.1 mole) was added to a solution of 2,4,6-trichlorobenzenesulfonic acid (52.2 g, 0.2 mole) in 3-chloropropionitrile (51.3 g, 0.6 mole). The suspension was heated at 55-60° C., for 18 hours. At the end of the heating period, the mixture was cooled to room temperature, diluted with methylene chloride (150 ml), and filtered. The solid, thus obtained, was suspended in acetone (50 ml) and the suspension filtered and the product dried.

후처리

  1. temperatureAt the end of the heating period, the mixture was cooled to room temperature
  2. filtrationfiltered
  3. customThe solid, thus obtained
  4. filtrationthe suspension filtered
  5. customthe product dried

출처 및 근거

ORD 기록
ord-286eded3fc4740119c3ad4ed69bbb3ea
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068405

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