2,2,2-Trifluoroacetophenone → 2,2,2-Trifluoro-1-phenyl-ethanone oxime

HRID 975243노트

반응식

HRID 975243 반응식
[Cl-].[OH:2][NH3+:3].[F:4][C:5]([F:15])([F:14])[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O>C(O)C>[F:4][C:5]([F:15])([F:14])[C:6](=[N:3][OH:2])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 99052,2,2-TrifluoroacetophenoneHCID 21645Hydroxylamine HCl

생성물 1

HCID 6049312,2,2-Trifluoro-1-phenyl-ethanone oxime수율 80.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of hydroxylammonium chloride (13.9 g, 200 mmol) and 2,2,2-trifluoroacetophenone (17.4 g, 92 mmol) in absolute ethanol (150 ml) was heated at reflux for 1 h and then stirred at ambient temperature for 16 h. The solvent was evaporated in vacuo, the residue suspended in water (100 ml), filtered and washed with water (20 ml), n-heptane (20 ml) and dried to give 14.0 g 2,2,2-trifluoroacetophenone oxime.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 1 h
  3. customThe solvent was evaporated in vacuo
  4. filtrationfiltered
  5. washwashed with water (20 ml), n-heptane (20 ml)
  6. customdried

출처 및 근거

ORD 기록
ord-15feefc887b843909ce932fa4a8671a0
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05608069

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