Pyridine → 1-Phenyl-1-cyclopentanecarboxaldehyde oxime

HRID 975265

반응식

HRID 975265 반응식
[C:1]1([C:7]2([CH:12]=O)[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[OH:15][NH3+:16].N1C=CC=CC=1>C(O)C>[C:1]1([C:7]2([CH:12]=[N:16][OH:15])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 21645Hydroxylamine HClHCID 110951241-Phenylcyclopentane-1-carbaldehyde

생성물 1

HCID 736783341-Phenyl-1-cyclopentanecarboxaldehyde oxime수율 66%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of the above aldehyde (3.4 g, 20 mmol) and hydroxylammonium chloride (2.9 g, 42 mmol) in a mixture of absolute ethanol (30 ml) and pyridine (3.3 g, 42 mmol) was heated at reflux for 2 h. The solvent was evaporated in vacuo, the residue was treated with absolute ethanol (50 ml) and the suspension filtered. The solvent was evaporated from the filtrate in vacuo and the residue crystallised from a 4/1 mixture of n-heptane and ethyl acetate to give 2.5 g of 1-phenyl-1-cyclopentanecarboxaldehyde oxime.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2 h
  3. customThe solvent was evaporated in vacuo
  4. additionthe residue was treated with absolute ethanol (50 ml)
  5. filtrationthe suspension filtered
  6. customThe solvent was evaporated from the filtrate in vacuo
  7. customthe residue crystallised from a 4/1 mixture of n-heptane and ethyl acetate

출처 및 근거

ORD 기록
ord-4915c322d95c4864aebbd6f6a4943ce2
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05608069

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