Hydrochloric Acid → N-(5-ethylpyrimidin-4-yl)-4-[3-(1-benzylpiperidin-4-yl)propanoyl]aniline

HRID 976129노트

반응식

HRID 976129 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16]([C:18]2[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:26]1[C:31]([CH2:32][CH3:33])=[CH:30][N:29]=[CH:28][N:27]=1.Cl.C[O-].[Na+].CO>C(O)C>[CH2:32]([C:31]1[C:26]([NH:22][C:21]2[CH:20]=[CH:19][C:18]([C:16](=[O:17])[CH2:15][CH2:14][CH:11]3[CH2:12][CH2:13][N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH2:9][CH2:10]3)=[CH:24][CH:23]=2)=[N:27][CH:28]=[N:29][CH:30]=1)[CH3:33]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 199689164-Chloro-5-ethylpyrimidineHCID 199689194-[3-(1-Benzylpiperidin-4-yl)propanoyl]anilineHCID 23694274Sodium methanolate methanol

생성물 1

HCID 19968894N-(5-ethylpyrimidin-4-yl)-4-[3-(1-benzylpiperidin-4-yl)propanoyl]aniline수율 58.9%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To 10 ml of ethanol were added 0.23 g of 4-[3-(1-benzylpiperidin-4-yl)propanoyl]aniline and 0.13 g of 4-chloro-5-ethylpyrimidine, and after adding 2 ml of an ethanol solution of hydrochloric acid (containing 0.071 g of hydrochloric acid), the mixture was reacted under reflux for 2 hours. After cooling, a 28% sodium methylate-methanol solution was added to the reaction mixture to make it alkaline, and then the mixture was condensed under reduced pressure. The obtained residue was applied to silica gel column chromatography to obtain 0.18 g of the title compound as pale yellow crystal.

후처리

  1. customthe mixture was reacted
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter cooling
  4. customcondensed under reduced pressure

출처 및 근거

ORD 기록
ord-fc8d77730ea844e4a41c0bd46b991193
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05610303

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