Water → 9,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

HRID 976364노트

반응식

HRID 976364 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[C:11]2[NH:12][C:13](=O)[C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1.O.[OH-].[Na+]>O1CCCC1>[O:7]1[C:11]2[NH:12][CH2:13][C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 100133324,10-dihydro-9H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-9-oneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 218369669,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of 4 mmol of lithium aluminum hydride in 25 ml of anhydrous tetrahydrofuran is added 1 mmol of 9,10-dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]-diazepin-9-one. The mixture is refluxed for 12 hours and allowed to stand overnight. To the mixture is added dropwise 0.12 ml of water and then 6 ml of 1N sodium hydroxide. The mixture is extracted with ethyl acetate and the extract dried (Na2SO4). The volatiles are removed in vacuo to give the desired product as a solid.

후처리

  1. temperatureThe mixture is refluxed for 12 hours
  2. extractionThe mixture is extracted with ethyl acetate
  3. dry with materialthe extract dried (Na2SO4)
  4. customThe volatiles are removed in vacuo

출처 및 근거

ORD 기록
ord-ba7c12dac40c4359b640f242fb44ac24
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612334

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