Water → 2-(Pyridin-2-YL)benzoic acid

HRID 976405노트

반응식

HRID 976405 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([O:11]C)=[O:10].[OH-].[Na+].O>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([OH:11])=[O:10]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13417093Methyl 2-(2-pyridinyl)benzoate

생성물 1

HCID 157331752-(Pyridin-2-YL)benzoic acid수율 89.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 3.0 g of methyl 2-(2-pyridinyl)benzoate and 600 mg of sodium hydroxide in 50 ml of 9:1 methanol:water is refluxed for 4 hours. The reaction mixture is concentrated in vacuo and the residue dissolved in 50 ml of cold water. The solution is neutralized with glacial acetic acid and the resulting product filtered, washed with water, and dried to give 2.5 g of the desired product:M+=200.

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. dissolutionthe residue dissolved in 50 ml of cold water
  3. filtrationthe resulting product filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-d295a0de05fc4e93913dcf07b0ef8b45
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612334

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