Sodium Dithionite → 2,5,6-Triamino-4-Benzyloxypyrimidine

HRID 976939노트

반응식

HRID 976939 반응식
S(S([O-])=O)([O-])=O.[Na+].[Na+].[N:9]([C:11]1[C:12]([NH2:26])=[N:13][C:14]([NH2:25])=[N:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=O>O>[NH2:25][C:14]1[N:13]=[C:12]([NH2:26])[C:11]([NH2:9])=[C:16]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:15]=1

참가 물질

4

반응물 2

HCID 24489Sodium DithioniteHCID 1810292,4-Pyrimidinediamine, 5-nitroso-6-(phenylmethoxy)-

생성물 1

HCID 98160442,5,6-Triamino-4-Benzyloxypyrimidine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium dithionite is added in portions to a suspension of 17 g 5-nitroso-2,4-diamino-6-benzyloxy-primidine (8) in 300 mL H2O at 50° C. until the red nitroso compound is fully reduced. The free base is separated out by adding aqueous ammonia. The crude product is cooled, suctioned off and crystallized from water, to which activated charcoal and a trace of sodium dithionite is added yielding 9.

후처리

  1. customThe free base is separated out
  2. additionby adding aqueous ammonia
  3. temperatureThe crude product is cooled
  4. customcrystallized from water, to which activated charcoal
  5. additiona trace of sodium dithionite is added
  6. customyielding 9

출처 및 근거

ORD 기록
ord-5eed9d62d29b4ff89a5319ce5cc955cb
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612468

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