Hydrochloric Acid → N-nitro-N-methyl-L-phenylalanine

HRID 977003

반응식

HRID 977003 반응식
[CH3:1][NH:2][C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl.[N:15]([O-:17])=[O:16].[Na+]>O>[N+:15]([N:2]([CH3:1])[C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)([O-:17])=[O:16]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6951135N-MethylphenylalanineHCID 23668193Sodium Nitrite

생성물 1

HCID 54111718N-nitro-N-methyl-L-phenylalanine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
5 °C

실험 절차

N-Methyl-L-phenylalamne (2.50 g) was suspended in water (25 ml) and cone. HCl (1 ml) was addded, with stirring. The solution was cooled to 5° C. and solid sodium nitrite (1.35 g) was added to the stirred solution. After stirring at 5° C. for 1 h, the reaction mixture was partitioned between dichloromethane and water. The organic solution was washed with brine and dried (MgSO4). After filtration the solvent was evaporated to yield N-nitro-N-methyl-L-phenylalanine as a white solid.

후처리

  1. stirringAfter stirring at 5° C. for 1 h
  2. customthe reaction mixture was partitioned between dichloromethane and water
  3. washThe organic solution was washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationAfter filtration the solvent
  6. customwas evaporated

출처 및 근거

ORD 기록
ord-ba84df62857b43a99259d3b989f623be
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05612477

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