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Oxalic Acid → 1-(4-Indolyloxy)-2-(4-(2-naphthyl)piperidin-1-yl)ethane ethanedioate

HRID 977360
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인쇄 미리보기

반응식

HRID 977360 반응식
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[CH:7]=[CH:8][NH:9]2.[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[CH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C(=O)([O-])[O-].[K+].[K+].[C:36]([OH:41])(=[O:40])[C:37]([OH:39])=[O:38]>C(#N)C.C(OCC)(=O)C>[C:36]([OH:41])(=[O:40])[C:37]([OH:39])=[O:38].[NH:9]1[C:10]2[C:6](=[C:5]([O:4][CH2:3][CH2:2][N:27]3[CH2:28][CH2:29][CH:24]([C:15]4[CH:16]=[CH:17][C:18]5[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=5)[CH:14]=4)[CH2:25][CH2:26]3)[CH:13]=[CH:12][CH:11]=2)[CH:7]=[CH:8]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 971Oxalic AcidHCID 11430Potassium CarbonateHCID 106317214-(2-chloroethoxy)-1H-indoleHCID 220292644-(Naphthalen-2-yl)piperidine

생성물 1

HCID 867500051-(4-Indolyloxy)-2-(4-(2-naphthyl)piperidin-1-yl)ethane ethanedioate

시약·촉매·용매 2

HCID 6342
Acetonitrile
용매
HCID 8857Ethyl Acetate용매2회

실험 절차

A solution of 1-chloro-2-(4-indolyloxy)ethane, 4-(2-naphthyl)piperidine and 3 equivalents of potassium carbonate in acetonitrile was heated at reflux for 12 h. The mixture was cooled, diluted with ethyl acetate, and the organic layer was separated and washed with brine. The crude residue was purified by silica gel chromatography (dichloromethane/5% methanol in dichloromethane gradient eluent). The resulting free base was dissolved in ethyl acetate and precipitated with one equivalent of oxalic acid in ethyl acetate, to give the title compound in 29% overall yield as a white solid. mp. 119°-120° C. FDMS m/e=370 (M+ of free base).

후처리

  1. temperatureat reflux for 12 h
  2. temperatureThe mixture was cooled
  3. customthe organic layer was separated
  4. washwashed with brine
  5. customThe crude residue was purified by silica gel chromatography (dichloromethane/5% methanol in dichloromethane gradient eluent)
  6. dissolutionThe resulting free base was dissolved in ethyl acetate

출처 및 근거

ORD 기록
ord-4ef8abc5e2534d23a2360a4d889889eb
출처 데이터셋
uspto-grants-1997_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05614523

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