Hydrochloric Acid → 3'-{({2-[4-(Aminosulfonyl)phenyl]ethyl}[(E)-3-phenyl-2-propenoyl]amino)methyl}-N-[2-(1-pyrrolidinyl)ethyl][1,1'-biphenyl]-3-carboxamide hydrochloride

HRID 9776

반응식

HRID 9776 반응식
[NH2:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][N:13]([CH2:24][C:25]2[CH:26]=[C:27]([C:31]3[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([NH:39][CH2:40][CH2:41][N:42]4[CH2:46][CH2:45][CH2:44][CH2:43]4)=[O:38])[CH:32]=3)[CH:28]=[CH:29][CH:30]=2)[C:14](=[O:23])/[CH:15]=[CH:16]/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:47]>C(OCC)(=O)C>[ClH:47].[NH2:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][N:13]([CH2:24][C:25]2[CH:26]=[C:27]([C:31]3[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([NH:39][CH2:40][CH2:41][N:42]4[CH2:46][CH2:45][CH2:44][CH2:43]4)=[O:38])[CH:32]=3)[CH:28]=[CH:29][CH:30]=2)[C:14](=[O:23])/[CH:15]=[CH:16]/[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 219869933'-{({2-[4-(Aminosulfonyl)phenyl]ethyl}[(E)-3-phenyl-2-propenoyl]amino)methyl}-N-[2-(1-pyrrolidinyl)ethyl][1,1'-biphenyl]-3-carboxamide

생성물 1

HCID 219873523'-{({2-[4-(Aminosulfonyl)phenyl]ethyl}[(E)-3-phenyl-2-propenoyl]amino)methyl}-N-[2-(1-pyrrolidinyl)ethyl][1,1'-biphenyl]-3-carboxamide hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3′-{({2-[4-(Aminosulfonyl)phenyl]ethyl}[(E)-3-phenyl-2-propenoyl]amino)methyl}-N-[2-(1-pyrrolidinyl)ethyl][1,1′-biphenyl]-3-carboxamide (200 mg) was treated with 4 N hydrogen chloride in ethyl acetate to give the title compound (198 mg).

출처 및 근거

ORD 기록
ord-56cbd7e6389349c0b6ca51767f4aee7b
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091247B2

연결된 노트

불러오는 중…